{"id":142,"date":"2023-03-06T11:02:44","date_gmt":"2023-03-06T17:02:44","guid":{"rendered":"https:\/\/coco66.com\/new-drug-reduces-risk-of-major-cardiac-events-by-13\/"},"modified":"2023-03-06T11:02:44","modified_gmt":"2023-03-06T17:02:44","slug":"new-drug-reduces-risk-of-major-cardiac-events-by-13","status":"publish","type":"post","link":"https:\/\/coco66.com\/new-drug-reduces-risk-of-major-cardiac-events-by-13\/","title":{"rendered":"New Drug Reduces Risk of Major Cardiac Events by 13%"},"content":{"rendered":"

A new study published in the New England Journal of Medicine has shown that a newer drug called Nexletol, which contains the active ingredient bempedoic acid, can significantly reduce the risk of major cardiovascular events.[0]<\/a><\/sup><\/p>\n

The CLEAR Outcomes trial, which was funded by Esperion Therapeutics, enrolled 13,970 statin-intolerant patients between December 2016 and August 2019 across 32 countries.[1]<\/a><\/sup> Participants had to have LDL cholesterol levels of 100 mg\/dL or higher, and either a previous cardiac event or other risk factors for heart disease.[2]<\/a><\/sup><\/p>\n

The primary outcome studied was a composite of cardiovascular death, heart attack, stroke or coronary revascularization (a procedure to open blocked arteries).[3]<\/a><\/sup> Those taking bempedoic acid experienced a greater occurrence of some side effects than those taking a placebo, such as renal impairment, gout, gallstones, and elevated hepatic enzymes, which is likely a result of the drug's activity in the liver.[4]<\/a><\/sup> The side effects, however, did not result in people ceasing use of the drug at a greater rate.[2]<\/a><\/sup><\/p>\n

Results showed that patients taking bempedoic acid had a combined 13% lower risk of death from cardiovascular disease, nonfatal strokes and nonfatal heart attacks.[5]<\/a><\/sup> When heart attacks alone were looked at, the risk reduction was 23%, and patients taking the daily tablet were 19% less likely to need a stent or heart bypass operation.[6]<\/a><\/sup><\/p>\n

The drug is activated only in the liver, so it is unlikely to cause muscle aches, which is a common side effect of statins.[1]<\/a><\/sup><\/p>\n

Esperion announced the full results from the trial at the American College of Cardiology's Annual Scientific Session & Expo together with the World Congress of Cardiology, and the company believes it would be entitled to receive $300 million in partner milestone payments for including certain required cardiovascular risk reduction data in the EU label, and up to $140 million in partner milestone payments for other regulatory milestones, including inclusion of certain required cardiovascular risk reduction data in the US label.[6]<\/a><\/sup><\/p>\n

0. <\/span>“Bempedoic Acid, Approved to Treat LDL Cholesterol, Cuts Risk of Major CV Events by 13%” AJMC.com Managed Markets Network, 4 Mar. 2023, https:\/\/www.ajmc.com\/view\/bempedoic-acid-approved-to-treat-ldl-cholesterol-cuts-risk-of-major-cv-events-by-13-<\/a><\/p>\n

1. <\/span>“Bempedoic Acid Reduces Major Adverse Cardiovascular Events in Patients Who Cannot Tolerate Statins” Pharmacy Times, 4 Mar. 2023, https:\/\/www.pharmacytimes.com\/view\/bempedoic-acid-reduces-major-adverse-cardiovascular-events-in-patients-who-cannot-tolerate-statins<\/a><\/p>\n

2. <\/span>“CLEAR Trial Reported at ACC23 Finds Bempedoic Acid Lowers LDL Cholesterol, Reduces Risk of Serious …” Diagnostic and Interventional Cardiology, 4 Mar. 2023, https:\/\/www.dicardiology.com\/content\/clear-trial-reported-acc23-finds-bempedoic-acid-lowers-ldl-cholesterol-reduces-risk-serious<\/a><\/p>\n

3. <\/span>“Cleveland Clinic-Led Trial Shows That The First Drug Designed for Statin-Intolerant Patients Reduces Serious Cardiovascular Events” Cleveland Clinic Newsroom, 4 Mar. 2023, https:\/\/newsroom.clevelandclinic.org\/2023\/03\/04\/cleveland-clinic-led-trial-shows-that-the-first-drug-designed-for-statin-intolerant-patients-reduces-serious-cardiovascular-events\/<\/a><\/p>\n

4. <\/span>“Bempedoic acid improved heart health in patients who can't tolerate statins, study finds” ABC17News.com, 4 Mar. 2023, https:\/\/abc17news.com\/news\/2023\/03\/04\/bempedoic-acid-improved-heart-health-in-patients-who-cant-tolerate-statins-study-finds-2<\/a><\/p>\n

5. <\/span>“Here's an Alternative to Statins for Lowering Cholesterol” TIME, 4 Mar. 2023, https:\/\/time.com\/6259864\/cholesterol-statins-alternative-bempedoic-acid\/<\/a><\/p>\n

6. <\/span>“Esperion Announces the Full Results from the landmark Cholesterol Lowering via Bempedoic Acid” Marketscreener.com, 3 Mar. 2023, https:\/\/www.marketscreener.com\/quote\/stock\/ESPERION-THERAPEUTICS-IN-13479951\/news\/Esperion-Announces-the-Full-Results-from-the-landmark-Cholesterol-Lowering-via-Bempedoic-Acid-43165352\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A new study published in the New England Journal of Medicine has shown that a newer drug called Nexletol, which contains the active ingredient bempedoic acid, can significantly reduce the risk of major cardiovascular events.[0] The CLEAR Outcomes trial, which was funded by Esperion Therapeutics, enrolled 13,970 statin-intolerant patients between December 2016 and August 2019 […]<\/p>\n","protected":false},"author":2,"featured_media":141,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts\/142"}],"collection":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/comments?post=142"}],"version-history":[{"count":0,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts\/142\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/media\/141"}],"wp:attachment":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/media?parent=142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/categories?post=142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/tags?post=142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}