{"id":318,"date":"2023-05-16T23:03:18","date_gmt":"2023-05-17T04:03:18","guid":{"rendered":"https:\/\/coco66.com\/new-genetic-variant-offers-potential-protection-against-alzheimers-disease\/"},"modified":"2023-05-16T23:03:19","modified_gmt":"2023-05-17T04:03:19","slug":"new-genetic-variant-offers-potential-protection-against-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/coco66.com\/new-genetic-variant-offers-potential-protection-against-alzheimers-disease\/","title":{"rendered":"New Genetic Variant Offers Potential Protection Against Alzheimer’s Disease"},"content":{"rendered":"

New research has identified a genetic variant that may produce extreme resilience and protection against Alzheimer's disease.[0]<\/a><\/sup> The study followed an extended family in Colombia, where members develop Alzheimer's in their forties or earlier.[1]<\/a><\/sup> Many of the family members carry a genetic variant called the paisa mutation that inevitably leads to early-onset dementia.[2]<\/a><\/sup> However, the researchers identified a male family member with a second genetic mutation that protected him from dementia until the age of 67.[3]<\/a><\/sup> The mutation was found to be in a gene coding for a protein called reelin, which is associated with brain disorders, including schizophrenia and autism.[4]<\/a><\/sup> The mutation appears to limit the production of tau tangles, a hallmark sign of Alzheimer's, and protect the entorhinal cortex, a vital area involved in memory and learning.[5]<\/a><\/sup> The findings challenge the theory that Alzheimer's disease is primarily driven by amyloid plaques, which are the targets of several drugs recently approved by the US Food and Drug Administration.[6]<\/a><\/sup> The study suggests potential new avenues for treatment, but further research is required before this molecular pathway might be exploited to develop therapies.<\/p>\n

0. <\/span>“Researchers identify rare genetic resilience to Alzheimer\u2019s disease \u2013 study” Yahoo Canada Sports, 15 May. 2023, https:\/\/ca.sports.yahoo.com\/news\/researchers-identify-rare-genetic-resilience-150000435.html<\/a><\/p>\n

1. <\/span>“Rare genetic mutation delayed Alzheimer's in Colombian man” Interesting Engineering, 16 May. 2023, https:\/\/interestingengineering.com\/science\/rare-genetic-mutation-delayed-alzheimers<\/a><\/p>\n

2. <\/span>“How one man's rare Alzheimer's mutation delayed the onset of disease” Nature.com, 15 May. 2023, https:\/\/www.nature.com\/articles\/d41586-023-01610-z<\/a><\/p>\n

3. <\/span>“Alzheimer\u2019s disease: Researchers identify gene mutation that can delay onset of symptoms” News9 LIVE, 16 May. 2023, https:\/\/www.news9live.com\/health\/health-conditions\/alzheimers-disease-researchers-identify-gene-mutation-that-can-delay-onset-of-symptoms-2142429<\/a><\/p>\n

4. <\/span>“Second patient with ‘natural immunity' against Alzheimer's warded off disease for 20 years” Daily Mail, 15 May. 2023, https:\/\/www.dailymail.co.uk\/health\/article-12086313\/Second-patient-natural-immunity-against-Alzheimers-warded-disease-20-years.html<\/a><\/p>\n

5. <\/span>“Researchers discover second case of person resistant to Alzheimer\u2019s” EL PA\u00cdS USA, 15 May. 2023, https:\/\/english.elpais.com\/science-tech\/2023-05-15\/researchers-discover-second-case-of-person-resistant-to-alzheimers.html<\/a><\/p>\n

6. <\/span>“US man\u2019s rare Alzheimer\u2019s mutation delayed onset of disease” DTNEXT, 16 May. 2023, https:\/\/www.dtnext.in\/wellbeing\/2023\/05\/16\/us-mans-rare-alzheimers-mutation-delayed-onset-of-disease<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

New research has identified a genetic variant that may produce extreme resilience and protection against Alzheimer’s disease.[0] The study followed an extended family in Colombia, where members develop Alzheimer’s in their forties or earlier.[1] Many of the family members carry a genetic variant called the paisa mutation that inevitably leads to early-onset dementia.[2] However, the […]<\/p>\n","protected":false},"author":2,"featured_media":317,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts\/318"}],"collection":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/comments?post=318"}],"version-history":[{"count":1,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts\/318\/revisions"}],"predecessor-version":[{"id":319,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/posts\/318\/revisions\/319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/media\/317"}],"wp:attachment":[{"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/media?parent=318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/categories?post=318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/coco66.com\/wp-json\/wp\/v2\/tags?post=318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}