Study Finds Hydrochlorothiazide Ineffective in Reducing Risk of Kidney Stone Recurrence

A recent double-blind trial published in the New England Journal of Medicine explored the potential benefits of hydrochlorothiazide in preventing recurrent kidney stones. The trial randomized patients with calcium-containing kidney stones to receive hydrochlorothiazide at a dose of 12.5 mg, 25 mg, or 50 mg once daily or placebo once daily. After a median follow-up of 2.9 years, the results showed that kidney stone recurrence occurred in 59% of patients receiving hydrochlorothiazide and 59% of those receiving placebo.

The incidence of recurrence did not differ substantially among patients receiving different doses of hydrochlorothiazide.[0] Radiologic kidney stone recurrence occurred in 45%, 32%, 34%, and 49% of patients receiving 12.5 mg, 25 mg, 50 mg of hydrochlorothiazide, and placebo, respectively. Symptomatic kidney stone recurrence occurred in 38%, 40%, 28%, and 34%, respectively.

Overall, the results suggest that hydrochlorothiazide does not reduce the risk of kidney-stone recurrence.[1] However, the authors note that further studies are needed to determine if hydrochlorothiazide may be of benefit to certain subgroups of patients.

0. “Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence | NEJM”, 1 Mar. 2023,

1. “Daily Thiazide No Help in Preventing Recurrent Kidney Stones” Medpage Today, 1 Mar. 2023,

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